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Dear Eugenio,

Thank you very much. I have a quick question, my current freesurfer version is 7.3.2, to use this tool (https://secure-web.cisco.com/1PxLkH4-UIrzi9_C3898PIi4CkExgjVKiAe06jS6sjHlCsR...), would you recommend me to update to latest version like 8.x or 7.4.1?

Best, Ted ________________________________ From: Iglesias Gonzalez, Juan E. JIGLESIASGONZALEZ@mgh.harvard.edu Sent: Monday, March 23, 2026 14:37 To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Re: Automatic delineation of PAG and VTA using FreeSurfer

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Dear Ted, You can use this tool: https://secure-web.cisco.com/1PxLkH4-UIrzi9_C3898PIi4CkExgjVKiAe06jS6sjHlCsR... Cheers, /Eugenio

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Juan Eugenio Iglesias

http://secure-web.cisco.com/1Xre4BtsrrvvAc5mJYzR4URwHyk1yntBfisbOo0_oXGhIij8...

From: Huaiyu Liu huaiyu.liu@ucl.ac.uk Date: Monday, March 23, 2026 at 10:26 AM To: freesurfer@nmr.mgh.harvard.edu freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Automatic delineation of PAG and VTA using FreeSurfer

External Email - Use Caution Dear FreeSurfer Team,

I hope you are well. My name is Ted and I am a postdoc working at the UCL, faculty of brain science

I am working with high-resolution T1-weighted MRI data and would like to identify an automated approach to delineate the periaqueductal gray (PAG) and ventral tegmental area (VTA) at the individual participant level.

I was wondering whether FreeSurfer provides:

1) Automated segmentation or masks for PAG and/or VTA 2) If so, how precise these segmentations are (e.g., spatial resolution, validation), and 3) Whether these delineations are available at the single-subject level, rather than only in standard space

If FreeSurfer does not support this directly, I would also appreciate any recommendations for alternative tools or workflows.

Many thanks for your time and help in advance.

Best regards, Huaiyu Liu (Ted)