Thank you Bruce! Good! So, at least it doesn't seem an impossible thing to achieve!! Best, Markus

2014-03-12 13:21 GMT+01:00 Bruce Fischl fischl@nmr.mgh.harvard.edu:

Hi Markus

there is no way to know until you try it. There are many possible sources of variance depending on e.g. how uniformly they are calibrated, but you have to try and see.

cheers Bruce

On Wed, 12 Mar 2014, Markus Gschwind wrote:

Dear all,

...

I am planning to create a "local cortical thickness normal template" in order to test single patients against it.

For that purpose I was planning to use 50-100 MPRAGE scans of healthy subjects (balanced for age range and sex).

My question is, if I should worry about the scanner where the data comes form. We have three Siemens Trios, the MPRAGES are more or less the same protocols.

• when the created template with standart deviation map comes from all

three scanners, can I test patients coming from all three scanners? Will it reduce sensitivity?

• when the created template comes from only one scanner, it is clear that

I will not be able to compare patients coming from another scanner against it.

Thank you!

Markus

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