Hi,

I have been working on a DBM based method to obtain longitudinal atrophy on some brain data. To quantify ROI, i use aseg.mgz. Several papers talk about Whole Brain, ventricular atrophy but do not actually define what substructures they use? It will be great if somebody can help me get the actual definition of whole brain and ventricles. For ex: WM Hypointensities are part of whole brain?, Since they increase in volume.

Thank you ,

Akshay University of Copehagen