Freesurfer's estimate of ICV ("eTIV") is designed to be insensitive to brain atrophy -- after all, it is an estimate of "intracranial volume", not brain volume. See the Buckner et al. (2004) paper for a validation of this.

cheers, -MH

On Fri, 2011-04-08 at 17:04 -0500, Gonzalo Rojas Costa wrote:

Hi:

I have an MRI of a 34 years old patient that have a brain atrophy, but with freesurefer I got an ICV of 1120 cc that is near the normal size for her age... I review the talairach transform, but I think it is ok... What could be the problem ?... Could I upload the MRI volume ?...

Sincerely,