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Dear FreeSurfer Team,

I hope this email finds you well. I am reaching out to seek clarification regarding the WMH-SynthSeg function in FreeSurfer.

I am interested in utilizing the WMH-SynthSeg function for the computation of white matter hypointensity. However, I am uncertain whether the resulting volume values undergo any form of normalization, such as division by intracranial volume, etc. Currently, I lack information on whether the obtained values are comparable across different subjects. Could you please provide insights or guidance on how the volume values are processed or standardized in WMH-SynthSeg? Understanding this aspect is crucial for ensuring the comparability of results across diverse study participants.

I appreciate your dedication to the development of FreeSurfer and look forward to your valuable insights.

Best regards, Liang Zhao Nanjing Medical University