Hi Massieh, There were some posts related to this a while back. If I recall correctly, the vertex-wise area measure (and likewise the vertex-wise volume measure) is highly dependent on the local mesh triangulation, and thus is not really a meaningful variable from a biological perspective. So, you would be better off analyzing the area of a whole label.

Best, -Mike H.

On Wed, 2010-04-28 at 09:54 -0400, Massieh Moayedi wrote:

Hi everyone,

I had two questions:

1. I was wondering if it's ok to run a glm to compare cortical surface

areas between two groups on a vertex-wide basis (just like a thickness analysis). Or is it better to extract the area of a label (as is the output of mri_anatomical_stats)?

2. The mri_anatomical_stats output includes 4 measures of curvature:

MeanCurv, GausCurv, Van Essen Folding index and Curvature Index. There was some discussion as to which of these was most appropriate for comparing sulcal folding (that is, essentially what they measure, correct?)- was there ever any final consensus?

Thank you.

Regards,

Massieh Moayedi B.Sc. (Hons) PhD Student Dr. Karen Davis' Lab Institute of Medical Science University of Toronto

Brain, Imaging and Behaviour- Systems Neuroscience MP 14-301 Toronto Western Research Institute University Health Network 399 Bathurst Street Toronto, Ontario Canada M5T 2S8 Tel: 416-603-5882

massih.moayedi@utoronto.ca mmoayedi@uhnres.utoronto.ca http://individual.utoronto.ca/PSMJC

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