Hi everyone,
I had two questions:
1) I was wondering if it's ok to run a glm to compare cortical surface areas between two groups on a vertex-wide basis (just like a thickness analysis). Or is it better to extract the area of a label (as is the output of mri_anatomical_stats)?
2) The mri_anatomical_stats output includes 4 measures of curvature: MeanCurv, GausCurv, Van Essen Folding index and Curvature Index. There was some discussion as to which of these was most appropriate for comparing sulcal folding (that is, essentially what they measure, correct?)- was there ever any final consensus?
Thank you.
Regards,
Massieh Moayedi B.Sc. (Hons) PhD Student Dr. Karen Davis' Lab Institute of Medical Science University of Toronto
Brain, Imaging and Behaviour- Systems Neuroscience MP 14-301 Toronto Western Research Institute University Health Network 399 Bathurst Street Toronto, Ontario Canada M5T 2S8 Tel: 416-603-5882
massih.moayedi@utoronto.ca mmoayedi@uhnres.utoronto.ca http://individual.utoronto.ca/PSMJC
Hi Massieh, There were some posts related to this a while back. If I recall correctly, the vertex-wise area measure (and likewise the vertex-wise volume measure) is highly dependent on the local mesh triangulation, and thus is not really a meaningful variable from a biological perspective. So, you would be better off analyzing the area of a whole label.
Best, -Mike H.
On Wed, 2010-04-28 at 09:54 -0400, Massieh Moayedi wrote:
Hi everyone,
I had two questions:
- I was wondering if it's ok to run a glm to compare cortical surface
areas between two groups on a vertex-wide basis (just like a thickness analysis). Or is it better to extract the area of a label (as is the output of mri_anatomical_stats)?
- The mri_anatomical_stats output includes 4 measures of curvature:
MeanCurv, GausCurv, Van Essen Folding index and Curvature Index. There was some discussion as to which of these was most appropriate for comparing sulcal folding (that is, essentially what they measure, correct?)- was there ever any final consensus?
Thank you.
Regards,
Massieh Moayedi B.Sc. (Hons) PhD Student Dr. Karen Davis' Lab Institute of Medical Science University of Toronto
Brain, Imaging and Behaviour- Systems Neuroscience MP 14-301 Toronto Western Research Institute University Health Network 399 Bathurst Street Toronto, Ontario Canada M5T 2S8 Tel: 416-603-5882
massih.moayedi@utoronto.ca mmoayedi@uhnres.utoronto.ca http://individual.utoronto.ca/PSMJC
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