Hi Laurel and Johannes

Satra Ghosh published a paper a few years ago using FS on pretty young subject's and found that at least the registration component was not biased by age:

https://www.ncbi.nlm.nih.gov/pubmed/20621657

Have you tried running your datasets to see how things work? I think the general experience is that by 6 or 7 things work pretty well. I'll cc Satra so he can disagree if he wants :)

cheers Bruce

On Mon, 9 Jul 2018, Mohn, Johannes wrote:

External Email - Use Caution

Dear FS Experts and Community,

we would like to run the recon-all -all pipeline on structural T1w images in a pediatric sample ages 6-9. We intend to assess cortical thickness, surface area, and subcortical volume in both ROIs and for whole brain analyses with Freesurfer and are aware that using the available adult template and atlases may lead to misspecifications. Therefore, we hope you can answer these questions:

1. Are you aware of a pediatric template brain that is compatible with the Freesurfer CT and SA

pipeline?

2. Are you aware of a pediatric template brain that comes with a ROI atlas that is compatible with

the Freesurfer CT and SA pipeline?

3. If we build a study-specific template brain (potentially with an atlas), what are the technical

requirements to be compatible with the recon-all -all pipeline? Do you know which programs for study-specific template brains are compatible with Freesurfer?

We look forward to your response

Thank you,

Laurel and Johannes

Jacobs Entwicklungsstudie

Max-Planck-Institut für Bildungsforschung

Max Planck Institute for Human Development

Lentzeallee 94

14195 Berlin

Tel.: 030-824 06 371

E-Mail: jacobs-studie@mpib-berlin.mpg.de