I only have anecdotal evidence based on 4 subjects, but I found that using the FLAIR results in much better surface reconstruction than the multiecho. In my experience (with kids age 12-16), the pial surface was underestimated when I used the multiecho.

________________________________________ From: freesurfer-bounces@nmr.mgh.harvard.edu [freesurfer-bounces@nmr.mgh.harvard.edu] on behalf of Bruce Fischl [fischl@nmr.mgh.harvard.edu] Sent: Saturday, December 14, 2013 1:10 PM To: roberto.viviani@uni-ulm.de Cc: Andre van der Kouwe; Freesurfer@nmr.mgh.harvard.edu; Eberhard.Pracht@dzne.de Subject: Re: [Freesurfer] Dura/pial reconstruction: FLAIR vs. multiecho

Hi Roberto

I think a T2-space FLAIR is your best bet. We have very little experience with other FLAIR and/or/ T2s, but those seem to work well. They are *much* higher SNR than the T2* maps that one can get from an memprage where the last echo is only around 7ms.

cheers Bruce On Sat, 14 Dec 2013, roberto.viviani@uni-ulm.de wrote:

Dear all,

starting from the version of March of this year, FreeSurfer supports the use of co-acquired FLAIR images to separate the dura from the gray matter. Some years ago, the idea about solving the same problem was to use multi-echo MPRAGE images. I am starting a new project, in which I am planning to acquire structural images, and I would like to know something more about these two ways of addressing the dura problem.

-- is there any experience on the superiority of the FLAIR approach, or is there any published evaluation of it / comparison with the MEMPRAGE approach (such as the van der Kouwer et al. 2008 paper on the MEMPRAGE) (I looked for it in scholar.google but could not find it)

-- are you planning to support the multi echo approach in the future, or is it going to be discontinued

I will also be very interested to hear from anyone who has had any experience with the FLAIR approach, or both.

Best wishes, Roberto

Roberto Viviani University of Ulm, Germany

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