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I saw this paper making the rounds recently (https://secure-web.cisco.com/1xpFxsKoB351lR8nLgcY1jLc9MKM9SFg22L-Gj-yGOtM9aW...) arguing that there are some areas where the cortex appears thicker with advancing Alzheimer Disease. The paper points towards prior publications from my own group which studies autosomal dominant AD where similar effects were found albeit did not reach significance. I've also seen this unexpected directional reversal in other cohorts. For aging I've seen it as far back as 2004 (https://secure-web.cisco.com/1exfvo1PFoqzlNRA3kd-j6t_3mH_q9fK-YbuHkw-gMEwFD5...). Have others seen this? I don't tend to think of their being true increases in thickness in neurodegenerative diseases, although I guess it could have occurred. I've always wondered if instead it had to do with some sort of bias or quirk that is coming into play when you have large displacement of this region due to expanding ventricles. I was just curious if other groups had seen this and if so with what disorders.

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