In the aging process there's overall cortical atrophy. Other papers like ours shows that too: https://surfer.nmr.mgh.harvard.edu/pub/articles/Oliveira_JAD2010.pdf

Cheers --------------------------------------------------------------------- Pedro Paulo de Magalhães Oliveira Junior Diretor de Operações Netfilter & SpeedComm Telecom -- www.netfilter.com.br -- For mobile: http://www.netfilter.com.br/mobile

On Mon, Aug 9, 2010 at 09:16, Zhangyuanchao woshizhangyc@yahoo.cn wrote:

hi, expert,

In a paper named "MRI of hippocampal volume loss in early Alzheimer's disease", I can see the average volume of hippocampus is 2133mm^3 for 279 normal controls with std=25 as well as 1631mm^3 for 330 AD subjects with std=34. However, in the aseg.stats, the volume of a normal subject is roughly 4000mm^3 or so, why the hippocampus volume of two samples differ so greatly due to age effect ( nearly about two times as much as the volume of the study).

Thanks!

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