Dear Doug,

I would like to be sure that I've understood the rules for the following contrast in a 2x2x2 design with diagnosis (D1, D2), gender (Male, Female) and handedness (Left, Right) as discrete factors.  D1MaleLeft D1MaleRight D1FemaleLeft D1FemaleRight D2MaleLeft D2MaleRight D2FemaleLeft D2FemaleRight

interaction between Diagnosis, Gender, and handedness  [ 1    -1    -1     1    -1     1     1    -1]

interaction between Gender and handedness for D1 [ 1    -1    -1     1     0     0     0     0]/2 interaction between Gender and handedness for D2 [ 0     0     0     0    -1     1     1    -1]/2

interaction between Diagnosis and handedness for Males [ 1    -1    0     0    -1     1     0    0]/2 interaction between Diagnosis and handedness for Females [ 0    0     1    -1    0     0     -1    1]/2

interaction between Diagnosis and Gender for Left [ 1    0    -1    0    -1     0     1    0]/2

interaction between Diagnosis and Gender for Right [ 0    1     0    -1    0    -1     0    1]/2

Thanks in advance,  Jose

--- Jose L. Cantero, Ph.D. Laboratory of Functional Neuroscience Department of Physiology, Anatomy and Cell Biology University Pablo de Olavide Ctra. de Utrera, Km.1 41013 - Seville - Spain - Phone: +34 954 977433 Fax: +34 954 349151 Email: jlcanlor@upo.es http://www.upo.es/neuroaging/en/