Dear FreeSurfers,
I have two discrete and binary factors (Dx: patients vs. controls; Sex: female vs. male), one continuous variable (Age), one nuisance factor (IQ). If there is a 3-way interaction of Dx x Sex x Age, regressing out IQ, is the following interpretation correct?
Red/yellow: In females (vs. males), the Age effect of cortical thickening is stronger in patients (vs. controls). Blue/cyan: In females (vs. males), the Age effect of cortical thinning is stronger in patients (vs. controls).
Note. by stronger, I mean greater magnitude without sign.
Thanks, Daniel
The basic contrast is (PM-PF)-(CM-CF) If that is positive, then it will be red, otherwise blue
This opens up a lot of possibilities as to what is driving the interaction, so it is hard to come up with a sentence like the one you are trying to state
doug
On 02/20/2014 02:25 PM, Yang, Daniel wrote:
Dear FreeSurfers,
I have two discrete and binary factors (Dx: patients vs. controls; Sex: female vs. male), one continuous variable (Age), one nuisance factor (IQ). If there is a 3-way interaction of Dx x Sex x Age, regressing out IQ, is the following interpretation correct?
Red/yellow: In females (vs. males), the Age effect of cortical thickening is stronger in patients (vs. controls). Blue/cyan: In females (vs. males), the Age effect of cortical thinning is stronger in patients (vs. controls).
Note. by stronger, I mean greater magnitude without sign.
Thanks, Daniel
Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
Thanks, Doug! I guess in order to interpret the interaction correctly, I would need to extract the thickness value and plot the interaction.
Best, Daniel
-- Daniel (Yung-Jui) Yang, Ph.D. Postdoctoral Researcher Yale Child Study Center New Haven, CT Tel: (203) 737-5454 E-mail: yung-jui.yang@yale.edu
On 2/20/14 2:57 PM, "Douglas N Greve" <greve@nmr.mgh.harvard.edumailto:greve@nmr.mgh.harvard.edu> wrote:
The basic contrast is (PM-PF)-(CM-CF) If that is positive, then it will be red, otherwise blue
This opens up a lot of possibilities as to what is driving the interaction, so it is hard to come up with a sentence like the one you are trying to state
doug
On 02/20/2014 02:25 PM, Yang, Daniel wrote: Dear FreeSurfers,
I have two discrete and binary factors (Dx: patients vs. controls; Sex: female vs. male), one continuous variable (Age), one nuisance factor (IQ). If there is a 3-way interaction of Dx x Sex x Age, regressing out IQ, is the following interpretation correct?
Red/yellow: In females (vs. males), the Age effect of cortical thickening is stronger in patients (vs. controls). Blue/cyan: In females (vs. males), the Age effect of cortical thinning is stronger in patients (vs. controls).
Note. by stronger, I mean greater magnitude without sign.
Thanks, Daniel
_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edumailto:Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
-- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edumailto:greve@nmr.mgh.harvard.edu Phone Number: 617-724-2358 Fax: 617-726-7422
Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2 www.nmr.mgh.harvard.edu/facility/filedrop/index.html Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
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The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
yes, or do post hoc tests doug
On 2/21/14 6:35 AM, Yang, Daniel wrote:
Thanks, Doug! I guess in order to interpret the interaction correctly, I would need to extract the thickness value and plot the interaction.
Best, Daniel -- Daniel (Yung-Jui) Yang, Ph.D. Postdoctoral Researcher Yale Child Study Center New Haven, CT Tel: (203) 737-5454 E-mail: _yung-jui.yang@yale.edu_
On 2/20/14 2:57 PM, "Douglas N Greve" <greve@nmr.mgh.harvard.edu mailto:greve@nmr.mgh.harvard.edu> wrote:
The basic contrast is (PM-PF)-(CM-CF) If that is positive, then it will be red, otherwise blue This opens up a lot of possibilities as to what is driving the interaction, so it is hard to come up with a sentence like the one you are trying to state doug On 02/20/2014 02:25 PM, Yang, Daniel wrote: Dear FreeSurfers, I have two discrete and binary factors (Dx: patients vs. controls; Sex: female vs. male), one continuous variable (Age), one nuisance factor (IQ). If there is a 3-way interaction of Dx x Sex x Age, regressing out IQ, is the following interpretation correct? Red/yellow: In females (vs. males), the Age effect of cortical thickening is stronger in patients (vs. controls). Blue/cyan: In females (vs. males), the Age effect of cortical thinning is stronger in patients (vs. controls). Note. by stronger, I mean greater magnitude without sign. Thanks, Daniel _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu <mailto:Freesurfer@nmr.mgh.harvard.edu> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> Phone Number: 617-724-2358 Fax: 617-726-7422 Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2 www.nmr.mgh.harvard.edu/facility/filedrop/index.html Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/ _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu <mailto:Freesurfer@nmr.mgh.harvard.edu> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
freesurfer@nmr.mgh.harvard.edu
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Douglas Greve -
Douglas N Greve
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Yang, Daniel