freesurfer has what is called the 'longitudinal' processing stream which is intended for exactly this purpose. you will need v4.5.0 of freesurfer, as that version of recon-all contains the hooks to do this type of analysis.

for complete details on how this works, see: https://surfer.nmr.mgh.harvard.edu/fswiki/LongitudinalProcessing

n.

On Fri, 2010-02-12 at 18:10 -0300, Gonzalo Rojas wrote:

Hi:

I have three MRIs of the same patient taken at different dates/years... I need to compare the hippocampus volume (for example) between the three MRI... I want to compare also the cortical thickness between the three MRI... How can I do such computation ?...

Sincerely,

Gonzalo Rojas Costa Department of Radiology Las Condes Clinic Santiago Chile

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