Hi Bruce, Thank you that answers my question. We were not sure if CVS registration would improve the accuracy of the subcortical volumes. Thanks! Jennifer On Feb 27, 2014, at 10:46 AM, Bruce Fischl wrote:

Hi Jennifer

if you are just comparing volumes then I don't see why you need registration at all. Can you clarify? The nonlinear registration was already done as part of the segmentation procedure

Bruce On Thu, 27 Feb 2014, Jennifer Eastman wrote:

...

Hi All, I just wanted to bump this question back up.I am interested in comparing sub-cortical volumes across subjects in my data set. I am wondering if using the CVS registration step is useful in improving the accuracy of the sub-cortical volume measurements independently. I will not be examining the cortical thickness just sub-cortical. I have combed the literature that is available and watched the training video, but I am not clear if there is benefit to using CVS registration if I am just looking at the sub cortical structures. Thank you.

Jennifer

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Hi Jennifer

Lilla might want to chime in. They do improve the accuracy of alignment, so if you were looking at average fMRI results or something it would be a good thing to do. But once the structure volumes have been computed the alignment is no longer needed - you can just look at bar charts or scatter plots or something. Or maybe I am not understanding what you are trying to do?

cheers Bruce

On Fri, 28 Feb 2014, Jennifer Eastman wrote:

Hi Bruce,

I had a follow up question. In the training videos they seem to indicate that the CVS registration improves accuracy for subcortical and cortical structural analysis. Can you clarify for me what the best use of CVS is if not for improving the subcortical and cortical alignment for greater accuracy? What are the best uses for CVS registration? Thank you in advance! Jennifer

On Feb 27, 2014, at 10:46 AM, Bruce Fischl wrote:

...

Hi Jennifer

if you are just comparing volumes then I don't see why you need registration at all. Can you clarify? The nonlinear registration was already done as part of the segmentation procedure

Bruce On Thu, 27 Feb 2014, Jennifer Eastman wrote:

...

Hi All, I just wanted to bump this question back up.I am interested in comparing sub-cortical volumes across subjects in my data set. I am wondering if using the CVS registration step is useful in improving the accuracy of the sub-cortical volume measurements independently. I will not be examining the cortical thickness just sub-cortical. I have combed the literature that is available and watched the training video, but I am not clear if there is benefit to using CVS registration if I am just looking at the sub cortical structures. Thank you.

Jennifer

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The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.