Yes, you can do these types of things. You'll need to create an FSGD file. Search for FSGD on the wiki and go to the examples page, there's not an example of 3 groups and 2 covariates, but there are enough examples there that you can piece it together. After you have your FSGD file, run mris_preproc, mri_surf2surf to smooth, mri_glmfit, then mri_glmfit-sim to correct for multiple comparisons. There's a group analysis tutorial on the website too.

doug

marco battaglini wrote:

Hi to everybody, I am a very inexperienced users of FreeSurfer. I have 3 groups of subjects and I have run recon-all and checked the results for all the subjects (very good results).

Now what I need to do, is to calculate the differences in the regional cortical thickness between these 3 groups (using age and gender as covariates) and to perform multiple comparisons, in order to detect possible local differences in cortical thickness.

Is it possible to perform this kind of analysis also for comparing surfaces between different groups?

Could you give me a short "pipeline" about the steps I need to do, or redirect me to some focused documentation?

Thank's.

Marco

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