Hi Daniel,

1. yes. But why not include 6 month in your study if you have those scans??? You will get much more reliable slope estimates with 3 time points compared to 2, so including that time point will not only help for the image processing part, but also in your statistics (you gain power).

2. I am not familiar with the mprage flag and think it mainly affects the normalization. If you are sure you need it, then also add it to the -base and -long runs, just to be safe.

best, Martin

On 01/29/2014 09:08 AM, Daniel Ferreira wrote:

Dear experts,

I have two questions regarding the longitudinal stream:

• I am including Baseline and 12 months follow-up in my study.

However, I also have 6 months follow-up. I wonder if it is conceptually right to include these 6 months scans in template creation with the idea of increasing registration.

• I am applying the -mprage flag in the crossectional first step.

Should I use it in the -base and -longs steps too?

Thanks very much

Daniel Ferreira

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