Hello Freesurfer Experts,
I'm writing with a quick question about matched analysis.
We have a cohort of MRI data collected such that there are two controls for each case, and these 2 controls are each matched to a specific case using a propensity score algorithm (~400 subjects total). For our analysis, we would like to try to implement a matched (or paired difference) analysis of cortical thickness (across the whole surface, not .aparcs) in Freesurfer. However, based all the documentation I have been able to find it seems that FS permits only paired difference analyses using matched pairs. Is this correct? Might there any way to implement such an analysis in Freesurfer using matched trios instead?
We are open to using any Freesurfer version for this analysis, including dev, though the scans are currently reconned with FS 5.3.
Thank you so much for your consideration!
With kind regards,
Kevin
Kevin F. Dowling Clinical Research Coordinator Brain Genomics Laboratory Division of Psychiatric Neuroimaging Martinos Center for Biomedical Imaging Massachusetts General Hospital 149 13th Street Charlestown, MA, 02129 (p) 617.643.3215 Pronouns: He / Him / His
There is nothing to plug and play. I'm not even sure about the theory, but I'd guess you'd use something like a repeated measures anova or simply average the two controls together and do a simple paired test. Do you know what the theory would be behind your statitical test?
On 07/09/2018 01:27 PM, Dowling, Kevin Francis wrote:
Hello Freesurfer Experts,
I'm writing with a quick question about matched analysis.
We have a cohort of MRI data collected such that there are two controls for each case, and these 2 controls are each matched to a specific case using a propensity score algorithm (~400 subjects total). For our analysis, we would like to try to implement a matched (or paired difference) analysis of cortical thickness (across the whole surface, not .aparcs) in Freesurfer. However, based all the documentation I have been able to find it seems that FS permits only paired difference analyses using matched pairs. Is this correct? Might there any way to implement such an analysis in Freesurfer using matched trios instead?
We are open to using any Freesurfer version for this analysis, including dev, though the scans are currently reconned with FS 5.3.
Thank you so much for your consideration!
With kind regards,
Kevin
*Kevin F. Dowling * Clinical Research Coordinator Brain Genomics Laboratory Division of Psychiatric Neuroimaging Martinos Center for Biomedical Imaging Massachusetts General Hospital 149 13th Street Charlestown, MA, 02129 (p) 617.643.3215 Pronouns: He / Him / His
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Dowling, Kevin Francis