yes, it will be much more sensitive/specific. Note that you have to run the cross-sectional first in any case though

cheers Bruce On Mon, 11 Jun 2018, Глеб Макшаков wrote:

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Dear all, I’ve just started using FreeSurfer and I need your advice. I have two series of images made 1 year apart from each other. Is it correct to use a Longitudinal Stream to process those images instead of simple cross-sectional counting and then estimating the difference in volumes between them?

Regards,

Gleb Makshakov MD, neurologist City Clinical Hospital 31 City Center of Multiple Sclerosis and AID Neurology Department of FSBEI HE I.P.Pavlov SPbSMU MOH Russia

gleb.makshakov@gmail.com +79213912101