Not necessarily.  This error can arise if any of the columns are linearly dependent. But try rescaling first

On 5/9/2025 8:29 AM, Ane Gurtubay wrote:

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Dear Douglas,

whenever we get this error *ERROR: matrix is ill-conditioned or badly scaled*  as in https://www.mail-archive.com/freesurfer%40nmr.mgh.harvard.edu/msg74674.html https://secure-web.cisco.com/1oJ3YaCat1otNMsv9b4ieBxS300R4fr4eMozJ0nxWe7N3be6UiZPOz-7Qn1pHrV1BxBwuIglZvxsU8pwnpVYjSL8ZLJQaOWFLde82Ut6oMIZheJq9Kvq3I3UAQfPLBKszAL7mleZbDK3zkmaziKTn-cCAzmKHA6OkOObXz5Zq5Ms7wfM9pQEddmeNHHWQiRuxd6HrWWpBsQR92OBq2S8Y45FlBBgeD2kYjmbMJBJmi22_-GvPDswXQDAAZCbO2UnMRcmaCQEpmgAZgfMWu1aHvlehNfBD7Xf59euDmJqezZJwGS4HHMgQuHEmzB6wrbH9/https%3A%2F%2Fwww.mail-archive.com%2Ffreesurfer%2540nmr.mgh.harvard.edu%2Fmsg74674.html, should we normalize the values in the fsgd file or the design matrix (Xg.dat)?

Thank you in advance, Ane

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Ane Gurtubay Antolin, PhD Ikerbasque Research Fellow Basque Center on Cognition, Brain and Language (BCBL) http://www.bcbl.eu/en/ane-gurtubay-antolin http://secure-web.cisco.com/10Mht_1YL1Yjet8TT5lrE72xv1nVXLPfSiYFb6jv4xo-YOw5uvcwywM7LxcRARDiDPThoIqKdavbHrv6iP9NHelyvdYATT6WJEgCEzWacooqbajfLwInY_nVSp4VmstQNz0Vy1WrDwVBpk9HE1SehAOZbHdDmpTQh1M04XVDY_OHv6pNcDUvv6h05itlrMTdp-he_S9b7cRp2ibNJEPjr7RmXQFYh8fQc7lOvmSdFW685mWdyOTgbBpSuvRgKRxs_fKxyUMUdGNhHZaiPm9NUc5Te14WjjljeELk11An7uiN6SkX9qDmP6dG85a__d_iX/http%3A%2F%2Fwww.bcbl.eu%2Fen%2Fane-gurtubay-antolin