Thanks Doug,

After re-watching these tutorial videos, I think I've understood these questions. Really appreciated for your answer.

Regards

*-------------* Mr Xianwei Che PhD Candidate Monash Alfred Psychiatry Research Centre (MAPrc) Central Clinical School & the Alfred Monash University Level 4, 607 St Kilda Road, Melbourne 3004, Australia

On 4 September 2017 at 09:04, Douglas Greve greve@nmr.mgh.harvard.edu wrote:

On 8/27/17 4:35 AM, Xianwei Che wrote:

Dear freesurfer experts,

I am wring to ask a stupid question, which I did not find the answer in the mailing list.

I am going to run stats on the thickness data as described in the tutorial, do I have to run separately for each hemisphere? If I am not wrong, we have to specify the hemi in the data assembling stage. Are we able to run once for both hemis in the glm and correction stage?

When you run recon-all, it will processes both hemis. After that, eg, mris_preproc, you must specify the hemi

If not, I am a little confused in the correction stage, which we specify the --2spaces in the simulation. As indicated in the tutorial, this is for adjusting p for both hemis.

Right, if you are eventually going to analyze both hemis, then you need to correct for multiple comparisons across both hemispheres.

Another question is about subcortical areas. Do we have to run stats for the cortical and subcortical areas separately?

Do you mean an ROI volume or surface area analysis? Then, yes.

Thanks

*-------------* Mr Xianwei Che PhD Candidate Monash Alfred Psychiatry Research Centre (MAPrc) Central Clinical School & the Alfred Monash University Level 4, 607 St Kilda Road, Melbourne 3004, Australia

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