Hi Dan, yes it is possible. Algorithmically, it is actually no different than doing it in the surface. Just give mri_glmfit the functional volume stack instead of a surface stack.

doug

Dan Dillon wrote:

Hi FreeSurfers. Is it possible to regress functional data against a continuous variable in the volume? I'm analyzing a reward processing study that activates sub-cortical and cortical regions, and I'd like to regress those data against a continuous measure of depressive symptoms administered to each participant. I understand the basic fsgd/mri_glmfit approach from the FS tutorial, but I want to stay in the volume in order to examine sub-cortical structures (e.g., nucleus accumbens). Is this possible?

Thanks!

Dan Dillon, Ph.D.

Post-doctoral Fellow

Affective Neuroscience Lab

Dept. of Psychology, Harvard University

Phone: (617) 495-1889

E-mail: dillon@wjh.harvard.edu mailto:dillon@wjh.harvard.edu

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