Yes, I would recommend making some kind of adjustment. As with all such adjustments, the adjustment you choose will dictate how you interpret the results (eg, a eTIV adjustment means something different that an adjustment for whole brain volume). For surface area, I usually adjust the eTIV. It might seem strange to adjust surface area by a volume, but for a highly folded surface, the surface area actually goes up linearly with the volume. But adjusting by total surface area is ok too.

On 05/08/2017 02:29 PM, John Anderson wrote:

Dear Freesurfer experts, I know that the grey or white matter volume measures for the ROIs reported in "wmparc.mgz" can be adjusted for the total intracranial volume.... Is is correct to do the same for surfaces? I mean can the surface of an ROI (e.g. precentral) be adjusted to total surface area? If yes, this must be done for total white right or total left depending on the ROI if it is left or right, correct?

Thank you John

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