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Hello, We are in the midst of longitudinal data collection. Before diving into our first longitudinal structural processing, have a few questions: Does Synthseg include a longitudinal processing stream? If so, how does it compare to the Freesurfer Longitudinal Processing stream? In the past, including both a T1 and T2 has been recommended for optimal segmentations. I don't see any mention of including a T2 in the longitudinal workflow (https://secure-web.cisco.com/1Hs2Tl_vnSro2vTkaUDdxTgiD9pw3XNueD_u5Drjxzqa7lS...). Would it be worth including T2 scans if they are available? Thank you for your thoughts and guidance!

Stacey M. Schaefer, Ph.D. Leader of the MIDUS Neuroscience Project &

Co-Leader of the MIDUS Admin Core

Institute on Aging

2245C Medical Sciences Center

University of Wisconsin-Madison

1300 University Ave

Madison, WI 53706 USA

608-265-3486