FreeSurfer experts,

I am attempting to use the two stage model for longitudinal analysis, however I keep receiving an error message that my design matrix is poorly scaled. I'm curious, I've used the same format of design matrix on cross sectional without problem.

Anyway here is the command line input:

mri_glmfit --glmdir rh.AllSite.gender.group.Age.thickness.fwhm10.twoStage.glmdir \ --X DOSSDS.twoStage_AllSite_Gender_Group_Age.dat \ --y rh.testretest.thickness-spc.stack.fwhm10.mgh \ --C DiffDiagnosis_ControlMore_AcctSite_AcctGender_AcctAge_pairedAnalysis.DOSSDS.mtx \ --label rh.testretest.fsaverage.cortex.label \ --surf fsaverage rh

The error message is attached within file error_designMtx_12_19_16.txt

Additionally I've included my analysis script, all timepoint qdec file, temporal average qdec file, fsgd file, and design matrix. Any help would be extremely beneficial.

-Tim

Timothy Hendrickson Department of Psychiatry University of Minnesota Office: 612-624-6441 Mobile: 507-259-3434 (texts okay)