Thank you Michael. I have more questions on this:

1. Is there a method to calculate if I have global difference in thickness between groups? 2. How can I control for global thickness difference vertex-wise using freesurfer?

Best wishes, Tanja.

On Mon, Sep 5, 2011 at 7:42 PM, Michael Harms mharms@conte.wustl.edu wrote:

Regarding #2: Yes, if you a have global difference in thickness between groups, then it is appropriate to control for that in the same manner that one frequently controls for total brain volume in volumetric analyses.

cheers, -MH

...

Dear list,

I have two question:

1. Is it possible to do the asymmetry analysis in FS, I mean to

compare left and right hemispheres within one group?

2. Is it necessary to somehow control for global abnormality of

thickness while looking at regional abnormality, e.g. if one group has thinner brain overall, but also thinner brain in some regions? (Similar to dividing by total brain volume in volumetric analysis)

Thank you and best wishes, Tanja. _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

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