interestingly, in this case i think there may even be reason why white matter hyper intensities could be more common in our insular region of interest where we detected thinning. The disease is HIV and activated monocytes invade the perivascular spaces where they can cause inflamation, which the lit. seems to say can cause white matter hyper intensities. these virchow robin spaces are prominent around the insula and may in fact this may be the etiology of the changes there.
so i guess i should try and tease apart which it is, maybe add flair imaging.
thanks for the comments
greg
On 04/05/12, Bruce Fischl wrote:
Hi Greg,
yes, that can happen where they are hyper-intense on T2 and hypo-intense on T1 and thus look like GM on the T1. It's not that common since they are usually deeper, but we have seen it.
sorry Bruce
On Wed, 4 Apr 2012, Gregory Kirk wrote:
a collaborator just got a grant review that claimed
There's a possibility that changes in cortical thickness in the insula might be a consequence of lesions (MR-hyperintensities) in the white matter.
i would think that white matter hyper intensities would tend to enhance freesurfers ability to detect the white matter/grey matter boundary rather than cause an error.
any comments as to the correctness of my thinking would be appreciated.
thank you
greg
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