Dear Free-surfer Users: when comparing cortical thickness measurements between patients and healthy people by the means of independent -tests, would you recommend correcting by Bonferroni method and consider as significant a p-value given by 0.05/82 or going ahead and just forget about the correction? Any suggestion on that would be greatly appreciated.
Thanks! - francesca
Francesca Bagnato, MD NIB-NINDS-NIH 10 Center Drive Building 10, Room 5B16 Bethesda, MD, 20892 USA ph #: 001-301-402.6391 fax #: 001-301-402.0373
Hi Francesca,
why 82? Are you comparing by parcellation unit? The newer versions of tksurfer have false discovery rate correction built into it, you might try it out.
cheers, Bruce
On Mon, 15 Aug 2005, Bagnato, Francesca (NIH/NINDS) wrote:
Dear Free-surfer Users: when comparing cortical thickness measurements between patients and healthy people by the means of independent -tests, would you recommend correcting by Bonferroni method and consider as significant a p-value given by 0.05/82 or going ahead and just forget about the correction? Any suggestion on that would be greatly appreciated.
Thanks!
- francesca
Francesca Bagnato, MD NIB-NINDS-NIH 10 Center Drive Building 10, Room 5B16 Bethesda, MD, 20892 USA ph #: 001-301-402.6391 fax #: 001-301-402.0373
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Bagnato, Francesca (NIH/NINDS) -
Bruce Fischl