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Hi FreeSurfer experts,

I have harmonized across site and scanners on both thickness and area for a large cohort (500+ subjects).

We are seeing high covariance values when comparing the harmonized and non-harmonized area datasets and trying to understand what this means.

Can this be due to how area is calculated (the mean area of the adjacent triangles at a vertex)? Are all of the triangles the same size? Can you explain the calculation of area further in the context of how thickness and area are related?

Secondly, we haven’t seen much literature on harmonizing freesurfer area, though harmonization is well reported for thickness measures. Are you familiar with harmonization of area data?

Best, Tejaswi