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Hi Doug, thanks for the explanation. My question is more related to how we might go about knowing what are the high binding regions for any tracer? If I am going to do an FDG-PET study, will the HB region parameters be different from a [11C]-PK11195 study for example? And secondly, might be these be different across subjects? Thanks for your help. Previous email :You should read up on the MRTM2. Basically, when you run MRTM1, it computes a separate k2 for each voxel eventhough the k2 should be the same across the entire brain (since it actually refers to the reference region). With MRTM2, you estimate the single k2 value from high binding regions.
Usually, an intensive study is done with any new tracer in which they do arterial sampling and apply various kinetic models to determine which one fits best (including which regions to use for high binding in MRTM2). You should find this study for your tracer. For FDG, MRTM2 is not appropriate since it is irreversible.
On 3/27/19 4:27 AM, Shane Schofield wrote:
External Email - Use Caution
Hi Doug, thanks for the explanation. My question is more related to how we might go about knowing what are the high binding regions for any tracer? If I am going to do an FDG-PET study, will the HB region parameters be different from a [11C]-PK11195 study for example? And secondly, might be these be different across subjects? Thanks for your help.
Previous email : You should read up on the MRTM2. Basically, when you run MRTM1, it computes a separate k2 for each voxel eventhough the k2 should be the same across the entire brain (since it actually refers to the reference region). With MRTM2, you estimate the single k2 value from high binding regions.
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Greve, Douglas N.,Ph.D. -
Shane Schofield