Where they otherwise acquired in the same way? Same scanner, same TR, TE, flip angle, voxel size, coil, etc? If so, then you have a chance. I would still be a little worried about it because they are experiencing two different paradigms (even though some of the conditions are the same). Is there any test you could do that would make a reviewer feel better? Eg, do you have a subset of subjects who did both? If so, you could do a paired analysis and show that there was no difference. Alternatively, if there is a condition that you do not expect to change across the populations, you could show that there is no change.

good luck! doug

On 01/10/2014 06:02 PM, Cesar Echavarria wrote:

Hi freesurfers,

I have run 2 separate blocked fMRI experiments ,each on a different pool of subjects, with couple of conditions identical in both experiments. I would like to pool the data for the conditions in common across these 2 experiments/group of subjects. I was wondering if anyone had any insight as to whether this is statistically valid or if there are any complications I should take into consideration when interpreting the pooled data.

Thanks in advance for your help

Cesar

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