Hi Doug,

Sure, I hope these links help:

https://www.ncbi.nlm.nih.gov/pubmed/17204713 https://www.ncbi.nlm.nih.gov/pubmed/17204713 https://www.nature.com/articles/npjschz201631 https://www.nature.com/articles/npjschz201631

Indeed, such a functionality in PetSurfer will be much appreciated! We are currently analysing multi-tracer PET imaging in the same individuals (i.e. 18F-AV1451, 11C-PiB and 11C-PK11195, etc), so it will be fantastic to have a streamlined pipeline within the Petsurfer environment :) If I am not wrong, there might be an R package for this purpose but I will search again and let you know.

Thanks for your time.

Best Wishes, Elijah

On 25 Jan 2018, at 23:40, Douglas N Greve greve@nmr.mgh.harvard.edu wrote:

That would be a great thing to do if I could find the time/funding to do it:). I have not used that method. Can you send a paper? Maybe it is not too hard.

On 01/25/2018 06:37 PM, Elijah Mak wrote:

...

Dear Doug,

In addition to the MRTM approaches, I was wondering if you have any plans to implement other algorithms in PetSurfer, such as supervised cluster analysis for extracting reference tissue activity? I am working with [11C]PK11195 PET data (neuroinflammation), for which there is no suitable reference region in neurodegenerative conditions. Hope to get your take on this please.

Thanks very much.

Best Wishes, Elijah

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