Hi Stephanie

I’m not sure you can really compare their accuracy. Thickness is easier to interpret though and is also a point measure and relatively insensitive to head size, so is frequently an easier surrogate biomarker than surface area. That said, we have done studies of surface area change

Cheers Bruce

From: freesurfer-bounces@nmr.mgh.harvard.edu freesurfer-bounces@nmr.mgh.harvard.edu On Behalf Of Stephanie K Sent: Monday, January 25, 2021 1:09 PM To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Thickness vs surface area

External Email - Use Caution Hello,

I am performing analyses looking at brain measures for a neurodegenerative disorder. I wanted to ask whether the accuracy for surface area is as high as is for thickness? I would appreciate your advice or any references.

Thanks

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