Mithra,

We highly recommend using the same version of freesurfer to perform recon-all processing on a group of subjects. Processing with different versions introduces an extra level of variability in your study.

However, in looking at the ReleaseNotes page:

https://surfer.nmr.mgh.harvard.edu/fswiki/ReleaseNotes

The fixes from v4.0.0 to v4.0.1 were made to gui apps, and to fix some segfault problems unrelated to aseg processing, plus the versions are less than a month apart, so in your case, i think it ok to mix versions 4.0.0 and 4.0.1 (unless you have the cpu resources to redo them, then that is safest).

Nick

On Mon, 2008-02-11 at 10:55 -0600, Mithra wrote:

Hello,

We used Freesurfer version 4.0.0 for a many of our subjects and version 4.0.1 for the other subjects.

Will there be a difference between both the versions. We are comparing individual subjects brain (aseg stats) at 2 different instances. It so happens we are comparing the same subject's brain done with version 4.0.0 with his later structural scan analyzed with version 4.0.1.

We are looking at the Hippocampus and Amygdala volumes.

Thanks.

-- Regards, Mithra

Imaging Research Center University of Texas, Austin 3925-B W Braker Lane Austin. TX - 78759 Tel: (512) 232-5725 Fax: (512) 232-4202

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