Hi  Caroline

If your longitudinal study is unbalanced over time (ie. the timing of the serial measurements is different across subjects) and with such a relatively high amount of repeated measures (6) it is very likely that you will need a longitudinal linear mixed effects (lme) model  to properly analyze your data.  Repeated measures ANOVA is just a special case of an lme model with only a single random effect for the intercept term.

We have made available a link for anyone interested in downloading our Matlab-based lme toolbox that can be used to analyze Freesurfer Data.

You can find the lme tools here:

http://nmr.mgh.harvard.edu/~jbernal/

Please read the usage.txt file to get started with these tools. There are also some example data that can help you understand how to format your own data to work with these tools.

Best -Jorge

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De: Caroline Jiang csjiang@hawaii.edu Para: freesurfer@nmr.mgh.harvard.edu Enviado: Miércoles 17 de octubre de 2012 16:46 Asunto: [Freesurfer] Repeated measures ANOVA fsgd file

Hi,   I’m trying to set up my fsgd file for repeated measures ANOVA with two groups and 6 time points (0, 1, 2, 3, 4, 5) by following the example from here: http://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova   Does this look correct for the fsgd file?  Subject 2 is missing time points 2 and 5.   GroupDescriptorFile 1

Title RepeatedMeasures

Class Group1

Class Group2

Variables

TP0-vs-TP1 TP0-vs-TP2 TP0-vs-TP3 TP0-vs-TP4 TP0-vs-TP5 Input subject1_tp0 Group1 1 1 1 1 1 Input subject1_tp1 Group1 -1 0 0 0 0 Input subject1_tp2 Group1 0 -1 0 0 0 Input subject1_tp3 Group1 0 0 -1 0 0 Input subject1_tp4 Group1 0 0 0 -1 0 Input subject1_tp5 Group1 0 0 0 0 -1 Input subject2_tp0 Group1 1 1 1 1 1 Input subject2_tp1 Group1 -1 0 0 0 0 Input subject2_tp3 Group1 0 0 -1 0 0 Input subject2_tp4 Group1 0 0 0 -1 0 Input subject3_tp0 Group2 1 1 1 1 1 Input subject3_tp1 Group2 -1 0 0 0 0 Input subject3_tp2 Group2 0 -1 0 0 0 Input subject3_tp3 Group2 0 0 -1 0 0 Input subject3_tp4 Group2 0 0 0 -1 0 Input subject3_tp5 Group2 0 0 0 0 -1     I’m interested in the overall group effect [1 -1 0 0 0 0 0 ], overall time effect, and group-x-time interaction.   Is this the correct contrast for the overall time effect? 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1   What would be the contrast for group-x-time interaction?     Thanks! Caroline   _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

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