Do you want to do it on a voxel-wise (map) basis? I guess you could just run mri_concat subj1/lesionmap.mni152.mgz subj2/lesionmap.mni152.mgz ... subjN/lesionmap.mni152.mgz --o stack.lesionmaps.mgz Then run a voxel-wise GLM on the stack. This tricky. You'll probably want to smooth it some (mri_fwhm). When you run mri_glmfit make sure to add --no-prune. You should also use permutation when you do correction for multiple comparisons (mri_glmfit-sim)

On 3/23/2021 10:07 AM, XY XY wrote:

External Email - Use Caution

Thanks Douglas, "mri_convert lesionmap.mgz -at samseg.m3z lesionmap.mni152.mgz" worked fabulously after some tweaks in the command line!

What would be the best approach to compare population-wise lesion heat maps between groups of subjects using the output from SAMSEG? (the full FS pipeline cannot process my data due to brain defects and time restrictions).

Thanks for all the support for these fantastic tools!

Stay safe!

*-----------------------------------------------------* *David Olayinka Kamson, MD PhD* Clinical and Research Fellow /Joint Neuro-Oncology Program of/ /Johns Hopkins Medicine &/ /National Institutes of Health / dkamson1@jhmi.edu mailto:dkamson1@jhmi.edu

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