Hi Linda

I had an old address for Mike in the first email. I think this one is correct. Building a folding atlas is pretty quick, depending on how many subjects you have. You'll need to pick one subject, run mris_make_template to build a single-subject template (for each hemi), register everyone to it, rerun mris_make_template to build a multi-subject atlas, rerun mris_register with the new atlas as the target and iterate this procedure until it converges (atlas building and reregistering). Usually it does after only one additional round.

cheers Bruce

On Wed, 8 Jan 2014, Linda Zhang wrote:

Thanks Bruce! How long would it take to build an atlas?

What are your thoughts Mike?

On 7 January 2014 14:38, Bruce Fischl fischl@nmr.mgh.harvard.edu wrote:

...

Hi Linda

I actually don't know the ethnicity of the subjects in our atlas. I wouldn't expect it to be an issue for folding patterns, but it is possible. You could build your own atlas and redo the analyses if you want to see if that changes things. I'll cc Mike Chee who I think has looked at this question as well.

cheers Bruce

On Tue, 7 Jan 2014, Linda Zhang wrote:

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Hi Bruce,

I've been using Freesurfer to compare subcortical volumes and cortical thickness between Caucasian and Chinese controls. There are some significant findings, but the question of whether or not these may be biased due to the template has been raised (the assumption being that the majority of subjects used in the template are Caucasian). Is it possible to reduce the weight of the atlas during normalisation (or some other method to address the issue)? I would greatly appreciate your thoughts on this.

Cheers, Linda

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