Hi Pedro:

A) Who knows? Probably gray matter volume, but # of neurons is pretty far from what we measure and many things can change volume without changing # of neurons (e.g. degree of arborization), so it's really hard to say.

B) Depends on how severe the malformations are. For mild ones, yes, for severe ones, probably not. cheers, Bruce

On Wed, 19 Dec 2007, Pedro Paulo Oliveira Jr wrote:

Hello,

I have a couple of questions, not so technical.

A) In your opinion what would be the best measure for comparing number of neurons among subjects: Average cortical thickness or Volume of White matter.

B) Automatic parcelation and atlas based segmentation is a valid approach for patients with severe cortical malformation?

Thanks in advance for your help.

Best Regards

Pedro Paulo Jr.

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