Hi Goulven,

we've applied it to tons of Alzheimer's cases and other similar ones with huge ventricles, and it's usually no problem. Particularly in the new (not quite officially released) version in which ventricular size is normalized out.

cheers, Bruce

On Fri, 21 Oct 2005, Goulven Josse wrote:

Dear freesurfers,

We are trying to analyse data from patients who had an early stroke. I did one automated parcellation (Fischl et al, 2004) in a patient with a peri-ventricular enlargement associated with a large overall atrophy of the injured hemisphere. I was pleased to find out that, even in the injured hemisphere, the anatomy was -apparently- well parcellated. I am now thinking of applying the parcellation to other subjects with a similar lesion and, possibly, to subjects with a much bigger, cortical, lesion.

Before going ahead, I am wondering if anyone had an opinion about whether it makes sense to use this parcellation in patients, while it was (i think) originally designed for normal brains. Variability is huge in normals but still ...

thanks ! Goulven Josse (Brain Research Imaging Center, U of Chicago)

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