Hi Stefan

I'm not sure I have an answer for you, except to say that the VD is kind of a grab-bag of areas that don't have much contrast in T1 images. The borders are mostly based on geometry. You could certainly test reproducibility, but accuracy for such a poorly defined thing might be more difficult

cheers Bruce On Thu, 27 Feb 2014, Stefan Du Plessis wrote:

Hello everyone

We are interested in measuring the dimensions of the ventral diencephalon as part of a general metabolic study.  We were wondering how accurate people consider freesurfer to be at measuring this region currently? Although some VDC freesurfer results have been published before (Goldman 2008) and look promising, we are not aware of any cross-validation studies in this region with freesurfer. We were wondering what other recommended automated/semi-automated techniques/software packages (Apart from manual tracing of course...) are available to help cross-validate morphological findings in this region specifically?

greetings

Stéfan

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Stéfan du Plessis Stellenbosch, South Africa