Hi Bruce,

Great, that will simplify things considerably. Thank you for the info.

Jon

On Fri, Apr 25, 2014 at 9:35 PM, Bruce Fischl fischl@nmr.mgh.harvard.eduwrote:

Hi Jon

yes, that works fine. The mprage gives better CNR/unit time in the cortex, but if you are really only interested in MEG that is probably a secondary concern (it would be important if you were doing e.g. a thickness study)

cheers Bruce

On Fri, 25 Apr 2014, Jon Houck wrote:

Hi all,

...

I'm building a scan protocol for what is primarily a MEG study, which needs T1 information for co-registration and T1/T2 information to construct an accurate BEM from the inner skull surface. It seems like the two multi-echo FLASH sequences at 5 and 30 degrees would give me all of the information that I need without an MPRAGE, but I'm not sure how well the two MEFs work in the standard Freesurfer pipeline.

Would it be reasonable to acquire no MPRAGE but two MEF sequences at 5 and 30 degrees, combine them following the method from https://surfer.nmr.mgh.harvard.edu/fswiki/MEF, and send the resulting T1 to recon-all? With my scan time constraints, the alternative would be to acquire a multi-echo MPRAGE and a single 5-degree MEF.

Thanks for any help on what is probably a naïve question.

Jon Houck

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