You can compute a vertexwise correction using gaussian random fields (instead of using clusters). This is done with mri_glmfit-sim, thought I don't think that many people use it.

doug

On 09/09/2013 09:11 AM, Bruce Fischl wrote:

Hi Damien

Doug can correct me if I'm wrong, but I don't think there is any easy way to do this except to assume that the number of independent tests is equal to the number of vertices, which is of course pretty conservative.

cheers Bruce

On Mon, 9 Sep 2013, Damien MARIE wrote:

...

Hello everyone, I'm using freesurfer for regression analyses and group analysis of cortical thickness, surface area, curvature and sulcal depth. I started to made illustrations and tables using the p < 0.05 FDR correction. However I have some p-value reaching 10^-32 and I would apply a Bonferroni correction. How determinate the number of independent vertices? Thanks a lot, best regards, Damien

Damien Marie - Doctorant / PhD student E-mail: damien.marie@u-bordeaux2.fr Phone: +33 (0)5 57 82 09 39 Homepage: www.gin.cnrs.fr/spip.php?article23&lang=en Researchgate: www.researchgate.net/profile/Damien_Marie/ _______________________________________________ GIN (Groupe d'Imagerie Neurofonctionnelle) UMR 5296 - Université Bordeaux II Ségalen - CNRS - CEA 146, rue Léo Saignat - Case 71 33076 Bordeaux cedex _______________________________________________

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