Hi Erin,

I can't really answer for the curvature, as I'm not sure how much it's smoothed, but the lGI in the surrounding 25 mm radius will definitely be affected (as it is computed at each point in circular region of interest of 25mm radius).

But for all variables, you can theoretically restrict your analyses in specific regions of interest, as long as the artefact is not affecting your inter subject registration (I however don't have any experience with this, maybe other can jump in the discussion for that issue).

Best,

Marie

On Aug 7, 2013, at 1:09 PM, Erin Browning brownin8@uwm.edu wrote:

Hello--

Our dataset has 130ish scans with a bad temporal lobe artifact and a minor parietal lobe artifact. This artifact has affected the normalization and thus the white matter/gray matter selection, which we've manually fixed. However, the temporal lobe artifact is bad enough that chunks of data are missing in the surfaces. How will this affect curvature and LGI? We saw we can constrain our cortical thickness analyses to an ROI using mri_glmfit. Can we do this with curvature and LGI, and will having chunks of data missing affect readings elsewhere in the brain?

Thank you, Erin Browning _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

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