You might want to take at look at the following article.

Bigler ED, Abildskov TJ, Wilde EA, et al. Diffuse damage in pediatric traumatic brain injury: a comparison of automated versus operator-controlled quantification methods. Neuroimage 2010;50:1017-26.

Cerebellar GM volumes were similar between analysis methods, whereas cerebellar WM volumes differed (likely due to differing boundary inclusion/exclusion criteria and challenges for image quantification due to the numerous folia of the cerebellum).

Hope this helps.

Tricia Merkley

--- On Fri, 5/13/11, McLean John (NHS Greater Glasgow & Clyde) johnmclean@nhs.net wrote:

From: McLean John (NHS Greater Glasgow & Clyde) johnmclean@nhs.net Subject: [Freesurfer] Cerebellum segmentation, auto vs manual reference? To: "freesurfer@nmr.mgh.harvard.edu" freesurfer@nmr.mgh.harvard.edu Date: Friday, May 13, 2011, 7:01 AM

Hi,   I’ve found some volume differences in the cerebellum between two groups I’ve been studying. I used freesurfer v4.5 to do the segmentation. I am looking for a reference to justify the use of Freesurfer and to say that it compares well with manual tracing of the cerebellum but I’m struggling to find a paper with that data. Can anyone comment or point me in the right direction?

The Fischl et al 2002 Neuron paper has a comparison of most subcortical regions but doesn’t include the cerebellum and other papers I’ve seen by Makris et al 03’ and 05’ looks to employ a more involved and detailed approach for the cerebellum rather than only running Freesurfer’s recon-all process.   Many Thanks John

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