Yes, it is accurate. Why do you think it's not? There's lots of validation stuff on the wiki. The subcortical gray matter structures are given below. Left_Thalamus) Right_Thalamus) Left_Thalamus_Proper) Right_Thalamus_Proper) Left_Caudate) Right_Caudate) Left_Putamen Right_Putamen Left_Pallidum) Right_Pallidum) Brain_Stem) Left_Hippocampus) Right_Hippocampus) Left_Amygdala) Right_Amygdala) Left_Accumbens_area) Right_Accumbens_area) Left_VentralDC) Right_VentralDC) Left_Substancia_Nigra) Right_Substancia_Nigra) Left_Cerebellum_Cortex) Right_Cerebellum_Cortex)

Eisenstein, Sarah wrote:

Thank you for your response. However, is this considered an accurate estimation of subcortical volume? As far as I know, Freesurfer is unable to estimate some deep subcortical structure volumes. So what is subcortical volume (as given by Freesurfer aseg.stats) composed of?

-----Original Message----- From: freesurfer-bounces@nmr.mgh.harvard.edu [mailto:freesurfer-bounces@nmr.mgh.harvard.edu] On Behalf Of Douglas N Greve Sent: Monday, January 10, 2011 4:39 PM To: Eisenstein, Sarah Cc: freesurfer@nmr.mgh.harvard.edu Subject: Re: [Freesurfer] (no subject)

The aseg.stats file takes into account partial voluming which is not taken into account when you simply sum up the subcortical structures because some of those structures will be partially volumed with white matter.

doug

Eisenstein, Sarah wrote:

...

Hello,

What goes into the calculation of subcortical volume? We have tried adding volumes of individual subcortical areas but the total does not equal the subcortical volume provided by aseg. Is the subcortical volume calculation accurate?

Thanks,

Sarah Eisenstein

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