Hi James,

I would not run upsampled data through the highres pipeline. (not even sure I would run highres data through that).

So you should sample to 1mm resolution. To be fair you should also resample the 1mm image to a new position (to also introduce interpolation artefacts there). You could use my make_upright script for that, which uses mri_robust_register to map the image to an upright and straight head position.

Best, Martin

On 20. Jul 2018, at 22:15, James Gullickson jgullick@umn.edu wrote:

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All,

I would like to compare cortical thickness between two timepoints.

Timepoint 1 has 1mm^3 data. Timepoint 2 has 0.8mm^3 data.

I realize that there are limitations with this change in resolution between timepoints and that no analysis is going to be perfect, but I am trying to come up with the best possible solution.

Would it work to resample both timepoints' raw data into 0.9mm^3 ( mri_convert --conform_size 0.9 invol outvol ), and then run the 0.9mm data through Freesurfer 6.0 submilimeter recon? If so, are there any special considerations I need to take into account after the initial recon, or would longitudinal processing after this point be per normal?

Thanks,

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