Actually, I have also been looking for cortical
thickness normative values. We have run our
first few research subjects with FreeSurfer (a
normal control and several patients with
neurodegenerative disorders), and I wanted to see
if the thickness values we're getting are in the
normal range. I have two papers: Salat et al.
(2004) and Fischl & Dale (2000) in Cerebral
Cortex. The Fischl and Dale gives average
thickness for gyral and sulcal regions. Am I
correct to guess that the average gyral and
sulcal regions are taken by averaging the
individual gyral and sulcal units from the
aparc.a2005s.stats files? The Salat et al.
article gives a global thickness measure--I was
wondering how I would calculate this?
Also, if thickness values are available for
individual parcellation units and/or whole lobes,
that would be very helpful as well. In
particular, the lobes would be helpful, as well
as ROIs most relevant for AD (e.g. entorhinal
cortex and temporal pole [Desikan et al., 2009]).
Thanks,
Dana
>
>
>----------------------------------------------------------------------
>
>Message: 1
>Date: Wed, 13 May 2009 08:54:59 -0400 (EDT)
>From: rahul(a)nmr.mgh.harvard.edu
>Subject: Re: [Freesurfer] Literature values for cortical thickness
>To: "Bruce Fischl" <fischl(a)nmr.mgh.harvard.edu>
>Cc: freesurfer(a)nmr.mgh.harvard.edu, Falk L?sebrink
> <falk.luese(a)gmx.net>
>Message-ID:
> <49194.70.23.239.45.1242219299.squirrel(a)mail.nmr.mgh.harvard.edu>
>Content-Type: text/plain;charset=iso-8859-1
>
>Hi Falk,
>
>We do indeed have cortical thickness values for each of the parcellation
>units for a range of subjects (healthly elderly, middle age and young
>controls and Alzheimer's disease subjects). Which parcellation units are
>you looking for? A whole lobe?
>
>Best,
>
>rahul
>
> > Hi Falk,
> >
> > we published some values in our Cerebral Cortex paper , but I suspect the
> > effective thickness will vary a bit as a function of pulse sequence, and
> > certainly it will vary with things like age. Rahul has probably tabulated
> > by parcellation unit if that helps.
> >
> > cheers
> > Bruce
> >
> > On Wed, 13 May
> > 2009, Falk Lüsebrink wrote:
> >
> >> Hi everyone,
> >>
> >>
> >>
> >> As I dont do a study in which I compare a group of subjects with some
> >> kind
> >> of abnormality with a control group I was looking for literature values
> >> for
> >> cortical thickness. The only paper I found which was written by von
> >> Economo
> >> et al. in 1925 doing a post-mortem analysis.
> >>
> >>
> >>
> >> Are there any more recent sources available which maybe even cover
> >> in-vivo
> >> values for regional cortical thickness? Actually Im looking for average
> >> values across the whole lobes.
> >>
> >>
> >>
> >> Thanks in advance,
> >>
> >> Falk
> >>
> >>
>
>
>
>------------------------------
>