Hello, I have worked quite a bit in the past with fs 5.3 on datasets which required a fair number of manual edits to the white matter volume in order to correct defects in the white matter surface. Typically, these edits take the form of removing voxels in the wm.mgz volume that have been incorrectly identified as white matter, usually near the pial surface caused by intensity artifacts resulting from motion. My experience in the past is that generating the white matter surface after edits to the wm.mgz volume will reliably change the geometry of the resulting surfaces.
However, on my current dataset, 1.5T adolescent brains with pervasive motion artifacts that do not meet the threshold for unusable data, absolutely no intervention I have done on the wm.mgz volume has any impact at all on the generation of the white matter surfaces. I am really very puzzled by this. All of the files that result from wm.mgz reflect the edits, however the aseg does not.
The resulting white matter surfaces always follow the aseg white matter definitions and never the wm.mgz edits. I feel as if there might be something I am missing but this protocol has reliably been used to do white matter edits in the past. I thought it may be an issue with fs 6 or the long stream, but I have tried the same edits in 5.3, 6, long and cross streams and nothing at all has worked.
Does anyone have any suggestions, or perhaps a hint that I am overlooking something common?
Thanks,
David P. Semanek, HCISPP
Research Technician, Posner Lab
Division of Child and Adolescent Psychiatry
Columbia University Medical Center
New York State Psychiatric Institute
1051 Riverside Drive, Pardes Bldg. Rm. 2424
New York, NY 10032
PH: (646) 774-5885
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