Hi Doug,
I ran a group analysis comparing a trait between two groups (Diseased vs
Controls) with one continuous variable (age), with the following design
matrices [1 -1 0 0] and [0 0 1 -1]. When I loaded the significance map and
the descriptor file, the age slope of the trait in Controls was positive
whereas the age slope of the trait in the Diseased cases was negative.
Therefore, comparing the intercept between the two groups does not really
give that much info, since the slopes are of opposite sign. What do you
believe would be the best course of action in order to compare the
age-corrected traits:
1) instead of age=0 maybe comparing the groups at age=mean?
2) or going with a DOSS model?
Thank you for your time,
Panos