Freesurfer

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30091 discussions

R: Re: cortical thickness normalization
by stdp82＠virgilio.it 04 Apr '13

04 Apr '13

Thank you very much, Michael! I have just an other important question, please. I'm performing cortical thickness analysis on three groups. One of this is a control group and I'm using it as support because I'm interested only to difference between the two groups of disease. These are my questions: 1- Is correct if I'm applying qdec, testing before a) disease 1 vs disease 2; b) controls vs disease 1 and c) controls vs disease 2. 2- Addictionally to cortical thickness that I'm reporting always as nuisance factor in qdec, I'd test some covariates. Taking in account my study design, could I test each covariates separately on my model using qdec? Thanks, Stefano ----Messaggio originale---- Da: mharms(a)conte.wustl.edu Data: 4-apr-2013 15.45 A: <stdp82(a)virgilio.it>, <freesurfer(a)nmr.mgh.harvard.edu> Ogg: Re: [Freesurfer] cortical thickness normalization If you're studying thickness, I'm a fan of using mean cortical thickness as the covariate (since thickness is what you're studying). I've posted on this in the past. cheers,-MH -- Michael Harms, Ph.D.-----------------------------------------------------------Conte Center for the Neuroscience of Mental DisordersWashington University School of MedicineDepartment of Psychiatry, Box 8134660 South Euclid Ave. Tel: 314-747-6173St. Louis, MO 63110 Email: mharms(a)wustl.edu From: <stdp82(a)virgilio.it> Reply-To: <stdp82(a)virgilio.it> Date: Thursday, April 4, 2013 7:21 AM To: <freesurfer(a)nmr.mgh.harvard.edu> Subject: [Freesurfer] cortical thickness normalization Hi list, I'm reading a lot of post on this list about cortical thickness normalization. I' m noting very different results on my data when I use mean thickness or ICV as nuisance factor than no factor. I'm confuse on this topic, could you advise the best way, please? Thanks, Stefano _______________________________________________ Freesurfer mailing list Freesurfer(a)nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.

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stats question
by j janssen 04 Apr '13

04 Apr '13

Hi, i read the following in a paper and would like to do the same: "At each vertex in each hemisphere, the proportion of total variance in cortical thickness (CT) accounted for by 2 linear regression models was compared: One that did not include an age-by-group interaction term, Model 1: [CT = intercept + (group * b1) + (age * b2)] and one that did, Model 2: [CT = intercept + (group * b1) + (age * b2) + (group * age * b3)]. This resulted in an F ratio map for each hemisphere showing the degree to which the inclusion of an age-by-group term increased the proportion of CT variance that was accounted for." i have set up the matrices for the 2 models. my questions: 1. do you think that i should test the effect of age in model 1 (contrast: 0 0 1) and the effect of age * group in model 2 (contrast 0 0 0 1 -1)? if not, what do you suggest? 2. do you have any idea how to combine these two analyses in a resulting F ratio map? thanks, -joost

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Fwd: Error with experimental design using FSGD
by Joshua deSouza 04 Apr '13

04 Apr '13

Hello Sir/Madam, I am currently running a statistical test using the FSGD method. I am encountering a problem in relation to the creation of the glmdir folder when I run the mri_glmfit function. I recieve an ERROR message that tells me that the design matrix (automatically generated) is ill conditioned or badly scaled, condo = 10565.7. All the steps before creating the glmdir folder have been done in accordance with the FSGD group analysis tutorial on the freesurfer wiki. The command line is : mri_glmfit --y lh.thomas4.10.mgh --fsgd thomas4.txt dods --C t4.txt --surf fsaverage lh --cortex --glmdir lh.thomas4.glmdir The FSGD file = thomas4.txt ( contains 2 groups and 5 variables) The data matrix = Xg.dat The contrast matrix = t4.txt There are 3 columns of variables that have discreet values of either 1 or 2. However I have tried this with another FSGD file (thomas3.txt) that contained 4 variables of which 2 were continous and the other 2 were in 1s' and 2s'. The contrast matrix of thomas3.txt = C.dat The design matrix of thomas3.txt = Xg1.dat I was able to generate a glmdir using mri_glmfit with thomas3.txt and generate a surface for tksurfer to use. The file created was the sig.mgh file which was then compared with the fsaverage files. However once I added another variable titled "voxel" in thomas4.txt, I received the error message. I did a correlation of the columns containing 1s and 2s in the FSGD file thomas4.txt using Matlab and have not found any significant correlation with each other. Please do advise on how to solve this issue and also from where the problem could stem from as I am unsure as to the nature of the problem. Thank You for your patience and assistance Joshua

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Problems with freesurfer after an upgrade to fedora 18
by Sidy Fall 04 Apr '13

04 Apr '13

After doing an upgrade from fedora 17 to fedora 18,I am trying to execute the installation tests, I can't start "$tkmedit", tksurfer or mri_convert. But freeview and qdec seem to be good. Tested with a CentOS4 or a CentOS6 recon-all,v 1.379.2.65 2013/02/19 22:34:56 nicks Exp $ -------- freesurfer-Linux-centos4_x86_64-stable-pub-v5.2.0 -------- Setting up environment for FreeSurfer/FS-FAST (and FSL) FREESURFER_HOME /usr/local/freesurfer FSFAST_HOME /usr/local/freesurfer/fsfast FSF_OUTPUT_FORMAT nii.gz SUBJECTS_DIR /usr/local/freesurfer/subjects MNI_DIR /usr/local/freesurfer/mni FSL_DIR /usr/local/fsl --------- Linux version 3.8.5-201.fc18.x86_64 (mockbuild@bkernel02) (gcc version 4.7.2 20121109 (Red Hat 4.7.2-8)) processor:Intel(R) Core(TM)2 Duo CPU E8500 @ 3.16GHz tcsh 6.18.00 (Astron) 2012-01-14 -------------------- When I do: tkmedit bert orig.mgz, it returned, ERROR: A segfault has occurred. This is not your fault, : but is most likely an unrecoverable error and has : made the program unstable. : : Please send the contents of the file .xdebug_tkmedit : that should be in this directory to freesurfer(a)nmr.mgh.harvard.edu : : Now exiting... : ----------------------- When I do: tksurfer bert rh pial, it returned, subject is bert hemi is rh surface is pial surfer: current subjects dir: /usr/local/freesurfer/subjects surfer: not in "scripts" dir ==> using cwd for session root surfer: session root data dir ($session) set to: surfer: /home/fallsi/Protocoles checking for nofix files in 'pial' Reading image info (/usr/local/freesurfer/subjects/bert) Reading /usr/local/freesurfer/subjects/bert/mri/orig.mgz surfer: Reading header info from /usr/local/freesurfer/subjects/bert/mri/orig.mgz ------------------- When I start mri_convert, I have this error message: mri_convert.c,v 1.179.2.7 2012/09/05 21:55:16 mreuter Exp $ reading from IM1... Segmentation fault (core dumped) --------------- the contents of .xdebug_tkmedit: tkmedit started: Wed Apr 3 11:43:32 2013 /usr/local/freesurfer/tktools/tkmedit.bin bert orig.mgz $Id: tkmedit.c,v 1.343 2011/03/01 01:41:22 nicks Exp $ $Name: stable5 $ Set user home dir to /home/fallsi/Protocoles Set subject home dir to /usr/local/freesurfer/subjects/bert Segfault Importing volume with MRIread xDebug stack (length: 5) 04: Volm_ImportData( this=0x27675600, isSource=/usr/local/freesurfer/subjects/bert/mri/orig.mgz ) 04: Importing volume with MRIread 03: LoadVolume( iType=0, isName=orig.mgz, ibConform = 0 ) 03: Reading data into volume 02: ParseCmdLineArgs( argc=3, argv=/usr/local/freesurfer/tktools/tkmedit.bin ) 02: Loading volume orig.mgz 01: main() 01: Parsing command line arguments 00: 00: ---------------------- Thank you in advance,

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mri_robust_register to obtain jacobian
by Jayachandra Raghava 04 Apr '13

04 Apr '13

Hello All, I am trying to use mri_robust_register to compute the symmetric rigid registration for inverse consistency. Is there a way to output the inverse consistent jacobian for the same registration? Thank you, Jay

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cortical thickness normalization
by stdp82＠virgilio.it 04 Apr '13

04 Apr '13

Hi list, I'm reading a lot of post on this list about cortical thickness normalization. I' m noting very different results on my data when I use mean thickness or ICV as nuisance factor than no factor. I'm confuse on this topic, could you advise the best way, please? Thanks, Stefano

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Doubt in the no. of dicom images
by Anupa AV 04 Apr '13

04 Apr '13

Dear All, I use Philips Achieva 3T scanner for the MRI study. When I open the Dicom folder, (say for MPR ) the no. of items I can see is 222 images (IM_xx) for one subject and for other subject, I find it as 166 images. Is it an error in saving the data or the no.of images vary among individuals. Thanks in advance for clarifying my doubt.

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Fw: Making cuts using tksurfer
by Anupa AV 04 Apr '13

04 Apr '13

----- Forwarded Message ----- From: Anupa AV <av.anupa(a)yahoo.com> To: Bruce Fischl <fischl(a)nmr.mgh.harvard.edu> Sent: Wednesday, April 3, 2013 11:57 AM Subject: Re: [Freesurfer] Making cuts using tksurfer Dear Sir, As you recommended, I have made a cut using plane option. Kindly see the attachment. My research interst is to make a coronal cut. I've done it by merging the standard FreeSurfer parcellation labels of the superior frontal gyrus, the rostral middle frontal gyrus and caudal middle frontal gyrus (after loading DKatlas). Then I cut the merged merged region using cut plane option. Now I want to make a coronal cut at Talairach coordinate y=26(say), so as to seperate dorsolateral prefrontal cortex from premotor cortex. Can you please tell me how to make a coronal cut at y=26? Thanks in advance for your response. ________________________________ From: Bruce Fischl <fischl(a)nmr.mgh.harvard.edu> To: Anupa AV <av.anupa(a)yahoo.com> Cc: "freesurfer(a)nmr.mgh.harvard.edu" <freesurfer(a)nmr.mgh.harvard.edu> Sent: Monday, April 1, 2013 6:15 PM Subject: Re: [Freesurfer] MAking cuts using tksurfer you might try using a cutting plane instead of having to draw the entire cut. cheers Bruce On Mon, 1 Apr 2013, Anupa AV wrote: > Dear All, > > How to explore the "cut" tools in freesurfer using tksurfer? > I'd like to make a cut along the vertex on the cortical surface (say, inflated) to divide medial and lateral components. > How to do it after loading DKatlas labels and I want to cut along the vertex to divde medial and lateral components.? > > Thanks in advance for your response. > > The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.

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Re: [Freesurfer] Bad Talairach Registration
by Bruce Fischl 03 Apr '13

03 Apr '13

Do you know why it has multiple frames? What kind of image is it? On Apr 3, 2013, at 10:51 PM, "Cherise R. Chin Fatt" <cherise.chinfatt(a)utdallas.edu> wrote: > Hello Bruce: > > I am using a T1-weighted image. > > > > > On Wed, Apr 3, 2013 at 9:44 PM, Bruce Fischl <fischl(a)nmr.mgh.harvard.edu> wrote: > Ae you trying to put a diffusion scan through recon-all? That won't work, it needs to be T1 weighted > Bruce > > > > On Apr 3, 2013, at 10:23 PM, "Cherise R. Chin Fatt" <cherise.chinfatt(a)utdallas.edu<mailto:cherise.chinfatt@utdallas.edu>> wrote: > > Hello: > > I have been trying to use FreeSurfer on an aging population and running into difficulties with Talairach Registration. I am able to run the demonstrate date, but when I run my own data I am getting some very weird results. I have attached screenshots of the different planes for one subject. I have tried this with 5 subjects and getting the same kind of results. > > In terms of scripting: I tried to run autorecon1 first and it failed with this error: ERROR: input(s) cannot have multiple frames! > > I changed the script and did the following (running one line at a time): > > setenv SUBJECTS_DIR test/DTI > recon-all -i DTI/00001.dcm -subjid again > > cd $SUBJECTS_DIR/again/mri/orig > mv 001.mgz multiframe.mgz > mri_convert -nth 0 multiframe.mgz 001.mgz > > recon-all -motioncor -subjid again > recon-all -talairach -subjid again > recon-all -nuintensitycor -subjid again > recon-all -normalization -subjid again > recon-all -skullstrip -subjid again > % checking registration > tkregister2 --mgz --s again --fstal > > If anyone can provide some insight in terms of what I am doing wrong or how to fix the registration would be greatly appreciated. > > Thank you, > Cherise. > -- > Cherise R. Chin Fatt; MSc > Doctoral Student in Cognition and Neuroscience > School of Behavioral and Brain Sciences > The University of Texas at Dallas > <Screen Shot 2013-04-03 at 8.39.26 PM.png> > <Screen Shot 2013-04-03 at 8.39.40 PM.png> > <Screen Shot 2013-04-03 at 8.39.54 PM.png> > _______________________________________________ > Freesurfer mailing list > Freesurfer(a)nmr.mgh.harvard.edu<mailto:Freesurfer@nmr.mgh.harvard.edu> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > The information in this e-mail is intended only for the person to whom it is > addressed. If you believe this e-mail was sent to you in error and the e-mail > contains patient information, please contact the Partners Compliance HelpLine at > http://www.partners.org/complianceline . If the e-mail was sent to you in error > but does not contain patient information, please contact the sender and properly > dispose of the e-mail. > > > > -- > Cherise R. Chin Fatt; MSc > Doctoral Student in Cognition and Neuroscience > School of Behavioral and Brain Sciences > The University of Texas at Dallas

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Bad Talairach Registration
by Cherise R. Chin Fatt 03 Apr '13

03 Apr '13

Hello: I have been trying to use FreeSurfer on an aging population and running into difficulties with Talairach Registration. I am able to run the demonstrate date, but when I run my own data I am getting some very weird results. I have attached screenshots of the different planes for one subject. I have tried this with 5 subjects and getting the same kind of results. In terms of scripting: I tried to run autorecon1 first and it failed with this error: *ERROR: input(s) cannot have multiple frames! * I changed the script and did the following (running one line at a time): setenv SUBJECTS_DIR test/DTI recon-all -i DTI/00001.dcm -subjid again cd $SUBJECTS_DIR/again/mri/orig mv 001.mgz multiframe.mgz mri_convert -nth 0 multiframe.mgz 001.mgz recon-all -motioncor -subjid again recon-all -talairach -subjid again recon-all -nuintensitycor -subjid again recon-all -normalization -subjid again recon-all -skullstrip -subjid again % checking registration tkregister2 --mgz --s again --fstal If anyone can provide some insight in terms of what I am doing wrong or how to fix the registration would be greatly appreciated. Thank you, Cherise. -- Cherise R. Chin Fatt; MSc Doctoral Student in Cognition and Neuroscience School of Behavioral and Brain Sciences The University of Texas at Dallas

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