On 2/22/19 7:58 AM, john Anderson wrote:
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Hi Dr Greve, I would like to use petsurfet to do kinetic modeling (KM), the pipeline is straightforward and easy to use. Thank you so much! I would appreciate any clarifications relevant to my questions bellow: 1) I understand that the flag "--km-ref" define the reference region for normalizing PET signal. in the linear below the reference region is cerebellum cortex. If we need to normalize to occipital just we change the numbers based on labels in aparc+aseg atlas? Yes.
--km-ref 8 47 --km-hb 11 12 13 50 51 52 --no-rescale
2) --km-hb define the high binding regions. Are these regions represent the regions that are pathologically involved where we expect it to have higher PET signal OR it represent the regions where PET tracer has the maximum binding in general regardless of pathology? I mean every tracer have high level in specific regions in the brain is this what the flag is referring too? I have not dealt with pathological cases with MRTM2. I would avoid using them for the HB region as their kinetics may be different than healthy tissue.
Thanks for any clarification, John
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